Sett vs Swain

Start your trades with Knuckle Down (Q): you rush toward your target, and your next two autos deal bonus damage based on their max health.

Cast Haymaker (W) right after taking damage: the stored Grit gives you a shield and extra damage, dealt as true damage in the center of the punch.

Don't back too early at low health: Pit Grit (passive) increases your health regen based on your missing health.

Stand between two enemies before Facebreaker (E): grabbed from both sides, they're stunned, otherwise only slowed.

Grab their tank with The Show Stopper (R) and slam them onto their carries: the damage around the impact depends on the bonus health of the target you grab.

Get out of the Nevermove (E) path as it comes back: it only roots on its return to Swain, then he can pull each rooted champion to him.

Leave the area as soon as Vision of Empire (W) appears: it strikes and slows 1.5 seconds later, and each champion hit gives him a Soul Fragment.

During Demonic Ascension (R), back off and hit from range if you can: he only drains nearby enemies, and his form ends when he stops draining.

If you have Grievous Wounds, apply it during Demonic Ascension (R): the drain heals him every second, and that healing keeps him alive.