Sett vs Warwick

Start your trades with Knuckle Down (Q): you rush toward your target, and your next two autos deal bonus damage based on their max health.

Cast Haymaker (W) right after taking damage: the stored Grit gives you a shield and extra damage, dealt as true damage in the center of the punch.

Don't back too early at low health: Pit Grit (passive) increases your health regen based on your missing health.

Stand between two enemies before Facebreaker (E): grabbed from both sides, they're stunned, otherwise only slowed.

Grab their tank with The Show Stopper (R) and slam them onto their carries: the damage around the impact depends on the bonus health of the target you grab.

Keep your health above 50%: below that, Blood Hunt (W) gives him speed toward you and attack speed, three times more below 25%.

When he drops below 50% health, finish him fast, with CC if you have any: Eternal Hunger (passive) then heals him with each auto, three times more below 25%.

If you have a dash, don't count on it to escape his held bite: Jaws of the Beast (Q) makes him follow all your movement, then leap behind you.

In teamfights, stay behind your tankiest allies: Infinite Duress (R) suppresses the first champion hit, and its range grows with his move speed.

If you have Grievous Wounds, apply it to him: his autos heal him at low health, and Infinite Duress (R) heals him for all the damage it deals.