Matchup

Syndra
Syndra
18%
82%

vs

47.8%

over 456 games

Cassiopeia
Cassiopeia
18%
82%
Heavy AP damageSustained DPSHeavy CC

Skill matchup

Build vs Cassiopeia

Build adapted to this matchup

Starting items

Doran's Ring
Health Potion
x2

Core build

Luden's Echo
1Mage
Hextech Rocketbelt
2Mage tank
Shadowflame
3vs Tank

Standard

Sorcerer's Shoes
4Magic pen
Rabadon's Deathcap
5Mage

Summoner spells

41281%
4612%

Anti AD

Plated Steelcaps
4vs AD
Zhonya's Hourglass
5vs AD

Anti Heal

Morellonomicon
6vs Heal

Anti AP

Mercury's Treads
4vs CC
Banshee's Veil
5vs AP

Anti Tank

Void Staff
5vs Tank
Stormsurge
vs Tank
Cryptbloom
vs Tank

DPS

Rabadon's Deathcap
Mage
Blackfire Torch
Mage
Cosmic Drive
Mage tank
Liandry's Torment
Mage tank
Seraph's Embrace
Mage

Other options

Mejai's Soulstealer
100.0% WR5 games
InspirationInspiration
First StrikeFirst Strike
Magical FootwearMagical Footwear
Biscuit DeliveryBiscuit Delivery
Cosmic InsightCosmic Insight
SorcerySorcery
TranscendenceTranscendence
Manaflow BandManaflow Band
Attack SpeedAdaptive ForceHealth Scaling

Power Spikes

Strength by game phase

Early (0-15)
Mid (15-30)
Late (30+)
SyndraSyndra
CassiopeiaCassiopeia
Aggressive
Neutral
Passive

Cassiopeia's abilities

Passive, spells and ultimate

Serpentine Grace (P)

All Move Speed bonuses are more effective on Cassiopeia.

Cooldowns

Cooldowns by spell rank

LevelQWER
33.5s24s0.75s
63.5s24s0.75s2m
93.5s22s0.75s2m
113.5s20s0.75s1m40
163.5s16s0.75s1m20
183.5s16s0.75s1m20

Playing against Cassiopeia

How to counter and exploit weaknesses

1

Turn away when she casts her R: you'll be slowed instead of stunned if you're not facing her.

2

Her DPS depends on landing Q (poison) — if she misses Q, she can't effectively spam E.

3

W prevents dashes: do NOT dash into the zone, go around it.

4

Cassiopeia doesn't have boots — slows are particularly effective against her.

Source: op.gg + LTL Engine · Patch 16.9.1 · May 9, 2026