Ziggs vs Locke

Poke with Bouncing Bomb (Q): its cooldown drops from 6 to 4 seconds, and a target slowed by Hexplosive Minefield (E) has a hard time dodging it.

Cast Satchel Charge (W) at your feet to escape or chase, even over a wall: the blast knocks you away without damaging you, and knocks back nearby enemies too.

Cast Mega Inferno Bomb (R) on a distant fight or a fleeing target: it reaches 5000 range, and the center of the blast deals more damage than the edge.

Siege towers from range, then cast Satchel Charge (W) on a tower that's almost down: below a health threshold, it's destroyed instantly.

Back instead of staying in lane at low health: Silver Stake (passive) adds damage to his autos that grows with your missing health.

Trade after Ashen Pursuit (E): it's his only instant movement, and its 10-second cooldown only resets if he gets a takedown.

During Soul Ignition (W), only hit him if you can kill him: at the end, he heals back part of the last damage taken, yours included.

Marked by Purgatory (R), stay above its threshold: if you have a heal or a shield, use it, because he seals marked enemies who drop below it.

If the Purgatory (R) artifact lands, hold the area where it fell: by picking it up, Locke raises his execute threshold for each sealed champion, for the rest of the game.