Recommended Build

Playing as Elise

Tips to maximize your impact

Start human, finish spider
Start in human form with Cocoon (E) then Neurotoxin (Q), strong on a high-health target. Finish in spider form with Venomous Bite (Q), strong on a low-health target.
Drop on your target to finish
In spider form, save Rappel (E) to finish or to escape: landing on your target empowers Spider Queen (passive), and Rappel's long cooldown leaves you vulnerable afterward.
Speed up your spiders
In spider form, cast Skittering Frenzy (W) once you're on your target: you and your spiderlings gain attack speed, and they attack the target you bite.
Gank early and often
Gank early and often: Cocoon (E) stuns the first enemy hit from range, and Elise is strongest before everyone has their items.

Versus

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Elise matchups

Global strengths and weaknesses

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Analyze a draft with Elise

Playing against Elise

How to counter and exploit weaknesses

Step up after a missed Cocoon
Step up when her Cocoon (E) misses you: it's her only stun, on a 12 to 10 second cooldown.
Don't stay low near her bite
Don't stay in melee range at low health: in spider form, Venomous Bite (Q) lunges at you and deals damage based on your missing health.
Ward the way into your lane
Ward the path between her jungle and your lane: when she ganks, Cocoon (E) stuns you from range as soon as it hits.
Drag the game out
If you survive her first minutes, play for time: Elise is strongest early and loses impact once everyone has their items.

Abilities and cooldowns

Spider Queen (P)

Human Form: When Elise's abilities hit an enemy, she gains a dormant Spiderling.Spider Form: Basic attacks deal bonus magic damage and restore health to Elise.